Buprenorphine: duration of blockade of effects of intramuscular hydromorphone

Drug Alcohol Depend. 1994 Apr;35(2):141-9. doi: 10.1016/0376-8716(94)90121-x.


Six opioid-dependent in-patients were maintained on daily sublingual doses of buprenorphine at 2, 6, and 12 mg/day for five days at each dose in a randomized, balanced sequence. Placebo buprenorphine was substituted for the next three days, and challenge doses of the mu agonist hydromorphone were administered on the three days. Planned comparisons in a 3-factor ANOVA showed dose-dependent hydromorphone effects, significant blockade of 'high' by the 12 mg buprenorphine dose, and no differences on hydromorphone-induced 'high' across 72 h of active buprenorphine. The data suggest that the blockade by buprenorphine of 'high' persists for at least 72 h after the last dose of buprenorphine.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Sublingual
  • Adult
  • Buprenorphine / administration & dosage*
  • Buprenorphine / adverse effects
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Hydromorphone / administration & dosage
  • Hydromorphone / adverse effects
  • Hydromorphone / antagonists & inhibitors*
  • Male
  • Neurologic Examination / drug effects
  • Opioid-Related Disorders / rehabilitation*
  • Single-Blind Method
  • Substance Withdrawal Syndrome / etiology
  • Time Factors


  • Buprenorphine
  • Hydromorphone