Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3

J Gen Virol. 1994 Sep;75 ( Pt 9):2489-93. doi: 10.1099/0022-1317-75-9-2489.

Abstract

Epstein-Barr virus (EBV) CD8+ cytotoxic T lymphocyte (CTL) epitopes are currently being considered for inclusion into subunit vaccines. Here we describe the characterization of five new CTL epitopes within EBV nuclear antigen 3 (EBNA3), confirming EBNA3 as a major target for CTL recognition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Viral / immunology*
  • CD8 Antigens / immunology
  • Callithrix
  • Cell Line, Transformed
  • Cell Nucleus / immunology
  • DNA-Binding Proteins / immunology*
  • Epitopes / analysis
  • Epitopes / immunology*
  • Epstein-Barr Virus Nuclear Antigens
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Lymphocyte Activation
  • Molecular Sequence Data
  • T-Lymphocytes, Cytotoxic / immunology*
  • Vaccines, Synthetic / immunology*
  • Viral Vaccines / immunology*

Substances

  • Antigens, Viral
  • CD8 Antigens
  • DNA-Binding Proteins
  • Epitopes
  • Epstein-Barr Virus Nuclear Antigens
  • Vaccines, Synthetic
  • Viral Vaccines