[Electrophoretic and kinetic properties of erythrocyte glucose-6-phosphate dehydrogenase (Gd) in hereditary enzyme deficiency. A new variant of glucose-6-phosphate dehydrogenase : Gd Kremenchug]

Y N Tokarev; N B Chernyak; A I Batishchev; N V Lamzina; G A Alexeyev

[Electrophoretic and kinetic properties of erythrocyte glucose-6-phosphate dehydrogenase (Gd) in hereditary enzyme deficiency. A new variant of glucose-6-phosphate dehydrogenase : Gd Kremenchug]

Nouv Rev Fr Hematol (1978). 1978;20(4):557-64.

[Article in French]

Authors

Y N Tokarev, N B Chernyak, A I Batishchev, N V Lamzina, G A Alexeyev

PMID: 752149

Abstract

A study of the activity of human erythrocyte G-6-PD has been completed on a great number of normal controls, coming from different regions of the USSR. This study has led to the discovery of a new variant of erythrocytic Gd, which was named "Kremenchug" from the origin of the patient. This new Gd, has a very low Km for G-6-P, and has a greater affinity for 2-deoxyglucose-6-phosphate. The maximal activity versus the pH of the medium is also characteristic of this new Gd.

Publication types

Case Reports
English Abstract

MeSH terms

Adult
Child
Electrophoresis
Erythrocytes / enzymology*
Glucosephosphate Dehydrogenase / analysis*
Glucosephosphate Dehydrogenase / genetics
Glucosephosphate Dehydrogenase Deficiency / enzymology
Glucosephosphate Dehydrogenase Deficiency / genetics*
Humans
Kinetics
Male
Mutation

Substances

Glucosephosphate Dehydrogenase