Alteration by Iloprost of the vasospastic effects of endothelin-1 in rabbit cerebral vessels

Neuroreport. 1994 May 9;5(9):1089-92. doi: 10.1097/00001756-199405000-00017.

Abstract

The reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.

MeSH terms

  • Animals
  • Basilar Artery / pathology
  • Basilar Artery / ultrastructure
  • Brain / pathology
  • Brain / ultrastructure
  • Cerebral Angiography
  • Endothelins / administration & dosage
  • Endothelins / antagonists & inhibitors*
  • Endothelins / pharmacology
  • Female
  • Iloprost / administration & dosage
  • Iloprost / pharmacology*
  • Injections, Intra-Arterial
  • Ischemic Attack, Transient / chemically induced
  • Ischemic Attack, Transient / pathology
  • Ischemic Attack, Transient / prevention & control*
  • Male
  • Neurons / drug effects
  • Neurons / ultrastructure
  • Rabbits
  • Subarachnoid Hemorrhage / pathology

Substances

  • Endothelins
  • Iloprost