Successful use of methadone in nociceptive cancer pain unresponsive to morphine

Palliat Med. 1994;8(2):153-5. doi: 10.1177/026921639400800209.

Abstract

Morphine is the mainstay of pain control in cancer patients. We describe three patients in whom adequate analgesia was not obtained with morphine, and discuss the role of morphine metabolites and the use of methadone as an alternative strong opioid analgesic.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Methadone / administration & dosage*
  • Methadone / adverse effects
  • Middle Aged
  • Morphine / administration & dosage*
  • Morphine / adverse effects
  • Neoplasms / physiopathology*
  • Pain Measurement
  • Pain, Intractable / drug therapy*
  • Palliative Care / methods*

Substances

  • Morphine
  • Methadone