Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat

M Burtin; J L Elghozi; D Laude; C Kleinknecht

Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat

Exp Nephrol. 1993 Jan-Feb;1(1):62-4.

Authors

M Burtin¹, J L Elghozi, D Laude, C Kleinknecht

Affiliation

¹ INSERM U192, Hôpital des Enfants-Malades, Paris, France.

PMID: 7521767

Abstract

Renal clearance of endogenous 5-HIAA has been shown to be similar to that of PAH in humans. The present study compared 5-HIAA and PAH clearances in rats. It showed that the clearance of 5-HIAA in rats was identical to that of inulin and creatinine. This suggests that in this species, 5-HIAA is only filtered and not secreted by the tubules in contrast to what is observed in humans.

Publication types

Comparative Study

MeSH terms

Animals
Biomarkers
Humans
Hydroxyindoleacetic Acid / blood
Hydroxyindoleacetic Acid / pharmacokinetics*
Kidney / metabolism*
Kidney Tubules / metabolism
Male
Metabolic Clearance Rate
Rats
Rats, Sprague-Dawley
Renal Circulation / physiology
Species Specificity
p-Aminohippuric Acid / blood
p-Aminohippuric Acid / pharmacokinetics

Substances

Biomarkers
Hydroxyindoleacetic Acid
p-Aminohippuric Acid