RNA selection. Aptamers achieve the desired recognition

Curr Biol. 1994 May 1;4(5):427-9. doi: 10.1016/s0960-9822(00)00093-2.

Abstract

In vitro selection procedures can generate RNA molecules, known as aptamers, that bind pre-determined ligands with an affinity and selectivity comparable to highly evolved protein molecules.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Arginine / metabolism
  • Base Sequence
  • Binding Sites
  • Chromatography, Affinity
  • Humans
  • In Vitro Techniques
  • Ligands
  • Molecular Sequence Data
  • RNA / genetics
  • RNA / metabolism*
  • Theophylline / metabolism
  • Vitamin B 12 / metabolism

Substances

  • Ligands
  • RNA
  • Adenosine Triphosphate
  • Arginine
  • Theophylline
  • Vitamin B 12