Digital indocyanine-green videoangiography of occult choroidal neovascularization

Ophthalmology. 1994 Oct;101(10):1727-35; discussion 1735-7. doi: 10.1016/s0161-6420(13)31433-x.


Background: Occult choroidal neovascularization (CNV) secondary to age-related macular degeneration occurs in the majority of patients with exudative maculopathy. Since occult CNV cannot be imaged clearly by fluorescein angiography, this condition is untreatable. The authors performed digital indocyanine-green videoangiography (ICG-V) on 657 consecutive eyes with occult CNV by fluorescein angiography to determine if this technique could be useful in enhancing the imaging of the neovascularization, and thus increasing treatment eligibility.

Materials and methods: Six hundred fifty-seven consecutive eyes with occult CNV were studied. The fluorescein and ICG angiograms were compared, and the percentage of patients potentially eligible for laser therapy based on ICG findings was calculated.

Results: Of 413 eyes with occult CNV without pigment epithelial detachments, focal areas of neovascularization were noted in 89 (22%). Overall, 142 (34.3%) eyes had lesions that were potentially treatable by laser photocoagulation based on additional information provided by ICG-V. Of the 235 eyes with occult CNV and vascularized pigment epithelial detachments, 98 (42%) were eligible for laser therapy based on ICG-V findings. The authors calculate that ICG-V enhances the treatment eligibility by approximately one third.

Conclusions: In diagnosing occult CNV, ICG-V is an important adjunctive technique to fluorescein angiography. This technique is especially useful in delineating occult neovascularization, neovascularization with overlying subretinal hemorrhage or serosanguineous fluid, and neovascularization associated with pigment epithelial detachments. The authors currently suggest that ICG-V be performed in eyes in which well-delineated neovascularization cannot be identified by fluorescein angiography. Based on their preliminary study, it can be expected that one in three patients with occult CNV potentially will be eligible for laser photocoagulation based on ICG-V. Further studies are necessary to confirm these findings.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angiography
  • Choroid / blood supply*
  • Choroid / pathology
  • Choroid / surgery
  • Female
  • Fluorescein Angiography / methods
  • Fundus Oculi
  • Humans
  • Indocyanine Green*
  • Laser Coagulation
  • Macular Degeneration / complications
  • Male
  • Middle Aged
  • Neovascularization, Pathologic / diagnosis*
  • Neovascularization, Pathologic / etiology
  • Neovascularization, Pathologic / surgery
  • Signal Processing, Computer-Assisted
  • Video Recording


  • Indocyanine Green