Prevalence of HCV-antibodies and HCV-RNA in donor blood in Tokushima Prefecture

Tokushima J Exp Med. 1994 Jun;41(1-2):9-15.

Abstract

The incidence of C100-3 among the blood specimens qualified for transfusion according to the conventional criteria was 1.1%. The incidence of C100-3 in donor blood in Tokushima Prefecture is not significantly different from that reported for all Japan. Of the donors positive for the conventional screening test and C100-3, 73.6% showed high ALT levels. For all antibodies, the incidence of HCV-RNA was very low in the donors positive for a single antibody, but was high in those positive for multiple antibodies. All of the donors showing the 3 antibodies were positive for HCV-RNA. While a test for multiple antibodies is thought to be effective for the screening of HCV, more blood needs to be discarded, having a serious cost-performance problem. The O.D. value for C100-3 and the 2nd antibody seem to be useful reference value for antibody titers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Donors*
  • Hepacivirus* / genetics
  • Hepacivirus* / immunology
  • Hepatitis Antibodies / blood*
  • Hepatitis C Antibodies
  • Humans
  • Incidence
  • Japan / epidemiology
  • Middle Aged
  • RNA, Viral / blood*

Substances

  • Hepatitis Antibodies
  • Hepatitis C Antibodies
  • RNA, Viral