Extramedullary Hematopoiesis During Therapy With Granulocyte Colony-Stimulating Factor

Arch Pathol Lab Med. 1994 Oct;118(10):1014-5.


Granulocyte colony-stimulating factor is a glycoprotein that promotes the proliferation and differentiation of neutrophils. It also results in an increase in circulating hematopoietic progenitor cells. We describe two cases of extramedullary hematopoiesis in patients receiving granulocyte colony-stimulating factor with chemotherapy for metastatic breast cancer.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / drug therapy*
  • Carcinoma, Ductal, Breast / secondary
  • Female
  • Granulocyte Colony-Stimulating Factor / pharmacology*
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Hematopoiesis, Extramedullary / drug effects*
  • Humans
  • Lymph Nodes / pathology*


  • Granulocyte Colony-Stimulating Factor