The CD19/CD21 signal transduction complex of B lymphocytes

Immunol Today. 1994 Sep;15(9):437-42. doi: 10.1016/0167-5699(94)90274-7.


CD19 and CD21 are B-cell surface molecules that associate with each other and with CD81 and Leu-13 to generate a signal transduction complex that is independent of the antigen receptor. Current studies, reviewed here by Thomas Tedder, Liang-Ji Zhou and Pablo Engel, indicate an important biological role for this protein complex in the regulation of B-cell development and activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / biosynthesis
  • Antigens, CD / immunology*
  • Antigens, CD19
  • Antigens, Differentiation / biosynthesis
  • Antigens, Differentiation / immunology
  • Antigens, Differentiation, B-Lymphocyte / biosynthesis
  • Antigens, Differentiation, B-Lymphocyte / immunology*
  • B-Lymphocytes / immunology*
  • Humans
  • Molecular Sequence Data
  • Receptors, Complement 3d / biosynthesis
  • Receptors, Complement 3d / immunology*
  • Signal Transduction / immunology*


  • Antigens, CD
  • Antigens, CD19
  • Antigens, Differentiation
  • Antigens, Differentiation, B-Lymphocyte
  • Receptors, Complement 3d
  • leu-13 antigen