CD20: a regulator of cell-cycle progression of B lymphocytes

Immunol Today. 1994 Sep;15(9):450-4. doi: 10.1016/0167-5699(94)90276-3.


CD20 is a B-cell-specific cell-surface molecule with four membrane-spanning domains, as well as cytoplasmic N- and C-terminal domains. Here, Thomas Tedder and Pablo Engel discuss the suggestion that CD20 is a regulator of transmembrane Ca2+ conductance and plays an important functional role in B-cell activation, proliferation and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / immunology*
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte / immunology*
  • B-Lymphocytes / immunology*
  • Calcium / metabolism
  • Cell Cycle / immunology*
  • Humans
  • Immunotherapy
  • Molecular Sequence Data
  • Phosphorylation
  • Sequence Homology, Amino Acid
  • Signal Transduction / immunology*


  • Antigens, CD
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte
  • Calcium