Nucleoside and nucleobase analog mutagens

Mutat Res. 1994 Dec;318(3):227-38. doi: 10.1016/0165-1110(94)90016-7.

Abstract

Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituents of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Repair
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mutagens / toxicity*
  • Mutation
  • Nucleosides / toxicity*
  • Purines / toxicity*
  • Pyrimidines / toxicity*

Substances

  • Mutagens
  • Nucleosides
  • Purines
  • Pyrimidines