Direct analysis of tumor-associated peptide antigens

Curr Opin Immunol. 1994 Oct;6(5):733-40. doi: 10.1016/0952-7915(94)90077-9.


Adoptive immunotherapy with tumor-specific cytotoxic T lymphocytes (CTLs) can induce tumor regressions in animals and in human cancer patients. Antigens recognized by CTLs from cancer patients are being sought as possible immunogens, a number of which have been identified during the past year. The ultimate result may be the development of novel peptide-based immunotherapies and a new understanding of the T-cell response to human cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Neoplasm / biosynthesis
  • Antigens, Neoplasm / chemistry
  • Antigens, Neoplasm / immunology*
  • Epitopes / analysis
  • Epitopes / immunology
  • Humans
  • Melanoma / immunology
  • Molecular Sequence Data
  • Peptides / immunology*
  • T-Lymphocytes / immunology


  • Antigens, Neoplasm
  • Epitopes
  • Peptides