Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

Neuroscience. 1994 Sep;62(2):327-31. doi: 10.1016/0306-4522(94)90366-2.


Experimental inflammation produced by an intraplantar injection of complete Freund's adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides substance P and calcitonin gene related peptide in the primary sensory neurons innervating the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin. Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of the immediate early gene c-fos in dorsal horn neurons, without modifying swelling and erythema. Elevation of the neurotrophin NGF in the periphery is a major contributor, therefore, of inflammatory pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / pharmacology
  • Calcitonin Gene-Related Peptide / biosynthesis*
  • Freund's Adjuvant
  • Gene Expression / drug effects
  • Genes, fos
  • Hypersensitivity*
  • Inflammation / physiopathology*
  • Nerve Growth Factors / biosynthesis
  • Nerve Growth Factors / immunology
  • Nerve Growth Factors / physiology*
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / physiology*
  • Rats
  • Skin / innervation*
  • Skin / physiopathology
  • Substance P / biosynthesis*
  • Time Factors
  • Turpentine


  • Antibodies
  • Nerve Growth Factors
  • Substance P
  • Freund's Adjuvant
  • Calcitonin Gene-Related Peptide
  • Turpentine