Angiogenesis inhibition: a review

Pharmacol Ther. 1994 Sep;63(3):265-311. doi: 10.1016/0163-7258(94)90027-2.


In this review we discuss the concept of anti-angiogenesis, which is the inhibition of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on various elements of the angiogenic process, including induction of vascular discontinuity, endothelial cell movement, endothelial cell proliferation, and three-dimensional restructuring of patent vessels. An effort is made to place the many different approaches to anti-angiogenesis research into a comprehensible structure, in order to identify problems of evaluation and interpretation, thereby providing a clearer basis for determining promising and needed directions for further investigation.

Publication types

  • Review

MeSH terms

  • Animals
  • Basement Membrane / metabolism
  • Cell Communication
  • Cell Division / drug effects
  • Cell Movement / drug effects
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Humans
  • Neovascularization, Pathologic / prevention & control*