The selectins and their ligands

Curr Opin Cell Biol. 1994 Oct;6(5):663-73. doi: 10.1016/0955-0674(94)90092-2.

Abstract

The selectins are a family of carbohydrate-binding proteins, or lectins, that have stimulated tremendous interest because of their involvement in a wide array of interactions between leukocytes and endothelial cells. Highlights of recent progress include an extension of the list of instances of selectin participation in inflammatory diseases, further definition of selectin carbohydrate specificities, and identification of their carbohydrate-based ligands.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carbohydrate Metabolism
  • Carbohydrate Sequence
  • Carbohydrates / chemistry
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / physiology*
  • Cell Movement / physiology
  • E-Selectin
  • Endothelium, Vascular / physiology
  • Humans
  • Inflammation / physiopathology
  • L-Selectin
  • Leukocytes / physiology
  • Ligands
  • Models, Molecular
  • Molecular Sequence Data
  • Oligosaccharides / chemistry
  • Oligosaccharides / metabolism
  • P-Selectin
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / physiology*
  • Sialyl Lewis X Antigen

Substances

  • Carbohydrates
  • Cell Adhesion Molecules
  • E-Selectin
  • Ligands
  • Oligosaccharides
  • P-Selectin
  • Platelet Membrane Glycoproteins
  • Sialyl Lewis X Antigen
  • L-Selectin