FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4

Drug Metab Dispos. 1994 Sep-Oct;22(5):811-4.

Authors

B V Karanam¹, S H Vincent, D J Newton, R W Wang, S H Chiu

Affiliation

¹ Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ.

PMID: 7530623

No abstract available

MeSH terms

Aged
Contraceptives, Oral / pharmacology
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System / metabolism*
Humans
In Vitro Techniques
Isoenzymes / antagonists & inhibitors
Isoenzymes / metabolism*
Male
Microsomes, Liver / enzymology*
Norpregnenes / pharmacology
Recombinant Proteins / metabolism
Tacrolimus / metabolism*

Substances

Contraceptives, Oral
Cytochrome P-450 Enzyme Inhibitors
Isoenzymes
Norpregnenes
Recombinant Proteins
Gestodene
Cytochrome P-450 Enzyme System
CYP3A protein, human
Cytochrome P-450 CYP3A
CYP3A4 protein, human
Tacrolimus