Endodermal sinus tumor arising from a dysgenetic gonad in a 46,XX female combined with müllerian agenesis

Gynecol Oncol. 1994 Dec;55(3 Pt 1):465-8. doi: 10.1006/gyno.1994.1324.


The occurrence of neoplastic transformation in a dysgenetic gonad of a female with 46,XX karyotype is very rare. Moreover, to our knowledge, a case of endodermal sinus tumor arising from that setting combined with Müllerian agenesis has not been reported. This case suggests the possibility of development of cancer in a dysgenetic ovary of a female even with 46,XX or Müllerian agenesis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Endodermal Sinus Tumor / blood
  • Endodermal Sinus Tumor / complications*
  • Endodermal Sinus Tumor / pathology
  • Female
  • Gonadal Dysgenesis / complications*
  • Gonadal Dysgenesis / genetics
  • Humans
  • Karyotyping
  • Mullerian Ducts / abnormalities*
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / complications*
  • Ovarian Neoplasms / pathology
  • alpha-Fetoproteins / metabolism


  • alpha-Fetoproteins