Colchicine toxicity--clinical features and treatment. Massive overdose case report

J Toxicol Clin Toxicol. 1995;33(1):71-7. doi: 10.3109/15563659509020219.


This is a report of colchicine poisoning in a 24-year-old woman. She developed multiple organ failure and bone marrow suppression after the suicidal ingestion of 50 (1 mg) colchicine tablets. The pancytopenia responded to granulocyte colony-stimulating factor 300 micrograms on days 4, 5, 6, and 8. Although anticolchicine monoclonal antibody administration is the only specific therapy described, intensive supportive care including granulocyte colony-stimulating factor administration can facilitate recovery from severe colchicine intoxication.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Cell Count
  • Colchicine / blood
  • Colchicine / poisoning*
  • Drug Overdose
  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Liver Function Tests
  • Multiple Organ Failure / chemically induced*
  • Multiple Organ Failure / physiopathology
  • Multiple Organ Failure / therapy*
  • Suicide, Attempted


  • Granulocyte Colony-Stimulating Factor
  • Colchicine