Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group on Vertical HCV Transmission

Lancet. 1995 Feb 4;345(8945):289-91. doi: 10.1016/s0140-6736(95)90277-5.


To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p < 0.001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p < 0.05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Breast Feeding
  • Female
  • Follow-Up Studies
  • HIV Infections / complications*
  • HIV Infections / transmission
  • Hepacivirus / immunology
  • Hepatitis Antibodies / blood
  • Hepatitis C / blood
  • Hepatitis C / complications
  • Hepatitis C / transmission*
  • Hepatitis C Antibodies
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical*


  • Hepatitis Antibodies
  • Hepatitis C Antibodies