Review
doi: 10.1016/0166-2236(94)90013-2.
Synuclein proteins and Alzheimer's disease
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- PMID: 7530877
- DOI: 10.1016/0166-2236(94)90013-2
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Review
Synuclein proteins and Alzheimer's disease
Trends Neurosci.
1994 Oct.
Abstract
In Alzheimer's disease, synuclein/NAC (non-amyloid beta component of Alzheimer's disease amyloid) proteins are found in presynaptic cholinergic nerve terminals that degenerate early in Alzheimer's disease, and they are also found closely linked to beta-amyloid fibrils in senile plaques. Synuclein/NAC proteins provide a potential molecular link between the degeneration of cholinergic nerve terminals, and the formation of plaques, and might have a primary role in their development.
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