[The functional characteristics of Gs-protein in the developing mammalian kidney]

Fiziol Zh Im I M Sechenova. 1994 Jul;80(7):81-7.
[Article in Russian]

Abstract

Characteristics of G-proteins were studied in renal medulla of rats and mice of different ages. It was established that G-protein alpha-subunit gene expression has a specific dynamics with maximum on the 5-8-th day of life and at the end of weaning. It was shown that vasopressin does not stimulate G-protein GTPase activity in membrane preparations from immature kidneys. The differences of G-protein chromatographic characteristics were revealed. It is suggested that the development of vasopressin sensitivity of the kidney is related with the changes in G-protein system.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism
  • Animals
  • Autoradiography
  • GTP Phosphohydrolases / metabolism
  • GTP-Binding Proteins / analysis
  • GTP-Binding Proteins / physiology*
  • Gene Expression Regulation, Developmental / physiology
  • Kidney Medulla / growth & development*
  • Kidney Medulla / metabolism
  • Male
  • Mice
  • Mice, Inbred CBA
  • Rats
  • Rats, Wistar
  • Vasopressins / physiology
  • Weaning

Substances

  • Vasopressins
  • GTP Phosphohydrolases
  • GTP-Binding Proteins