Synovial tissue response to treatment with Campath-1H

Arthritis Rheum. 1995 Feb;38(2):254-8. doi: 10.1002/art.1780380215.

Abstract

Objective: Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.

Methods: Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.

Results: Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.

Conclusion: These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Antigens, CD / adverse effects
  • Antigens, CD / analysis
  • Antigens, CD / therapeutic use*
  • Antigens, CD19
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • Antigens, Neoplasm*
  • Arthritis, Rheumatoid / therapy
  • B-Lymphocyte Subsets / cytology
  • B-Lymphocyte Subsets / immunology
  • CD3 Complex / analysis
  • CD4-Positive T-Lymphocytes / cytology
  • CD52 Antigen
  • Glycoproteins*
  • Humans
  • Immunohistochemistry
  • Knee Prosthesis
  • Lymphopenia / etiology
  • Paraffin Embedding
  • Synovial Membrane / immunology*
  • Synovial Membrane / pathology

Substances

  • Antigens, CD
  • Antigens, CD19
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Neoplasm
  • CD3 Complex
  • CD52 Antigen
  • CD52 protein, human
  • Glycoproteins