Transformation of fibroblasts into endothelial cells during angiogenesis

Cell Tissue Res. 1994 Dec;278(3):625-8. doi: 10.1007/BF00331383.


Light- and electron-microscopic autoradiography have been used to study fibroblast transformation into endothelial cells in the formation of new blood vessels during wound healing in rabbit ear chambers. When cultured fibroblasts labeled with tritium thymidine were transplanted autologously into the chambers, newly formed blood vessels contained endothelial cells labeled with tritium thymidine. This result suggests that fibroblasts play a pivotal role in angiogenesis, as progenitors of endothelial cells in newly formed blood vessels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Cell Differentiation
  • Cell Transplantation
  • Cells, Cultured
  • Ear / blood supply
  • Endothelium, Vascular / cytology*
  • Endothelium, Vascular / ultrastructure
  • Fibroblasts / cytology*
  • Fibroblasts / transplantation
  • Microscopy, Electron
  • Neovascularization, Pathologic*
  • Rabbits
  • Wound Healing