Administration of granulocyte colony-stimulating factor to neutropenic low birth weight infants of mothers with preeclampsia

J Pediatr. 1995 Mar;126(3):454-6. doi: 10.1016/s0022-3476(95)70468-x.


Nine low birth weight infants with neutropenia born to mothers with preeclampsia were treated with granulocyte-colony stimulating factor, 10 micrograms/kg intravenously, within 24 hours of birth and at 24-hour intervals for a maximum of three doses if neutropenia persisted. The absolute neutrophil count increased significantly in eight of the nine infants within 6 hours, and neutrophilia was sustained for at least 72 hours after administration of a single dose of granulocyte-colony stimulating factor.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Infant, Low Birth Weight* / blood
  • Infant, Newborn
  • Leukocyte Count
  • Neutropenia / etiology
  • Neutropenia / therapy*
  • Neutrophils
  • Pre-Eclampsia*
  • Pregnancy


  • Granulocyte Colony-Stimulating Factor