Effect of granulocyte colony-stimulating factor on preeclampsia-associated neonatal neutropenia

J Pediatr. 1995 Mar;126(3):457-9. doi: 10.1016/s0022-3476(95)70469-8.


Absolute neutropenia lasting longer than 72 hours after birth occurred in four very low birth weight neonates with a maternal history of severe pregnancy-induced hypertension, and was treated with recombinant granulocyte colony-stimulating factor for 3 days. Absolute neutrophil counts increased nearly four-fold within 48 hours; maximal values were recorded on the ninth day after the infusion was started. Total leukocyte counts subsequently decreased but remained in the normal range. It appears that recombinant human granulocyte colony-stimulating factor promotes a rapid increase in circulating neutrophils in these patients despite the possible presence of a circulating preeclampsia-associated inhibitor of neutrophil production.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Infant, Low Birth Weight* / blood
  • Infant, Newborn
  • Leukocyte Count
  • Male
  • Neutropenia / etiology
  • Neutropenia / therapy*
  • Neutrophils
  • Pre-Eclampsia
  • Pregnancy
  • Recombinant Proteins / therapeutic use


  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor