Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats

Brain Res. 1994 Nov 14;663(2):338-40. doi: 10.1016/0006-8993(94)91283-1.


The effects of intraperitoneal NG-methyl-L-arginine and N omega-nitro-L-arginine methyl ester, specific inhibitors of nitric oxide (NO) synthase, were examined on the pentylenetetrazol (PTZ)-induced seizures in rats. The incidence and latency for the onset of myoclonic jerks, clonic seizures, and tonic generalized extension were observed as specific parameters among PTZ-induced seizures. Both drugs preferentially suppressed the tonic generalized extension and prolonged the latency for the onset of each parameter, suggesting NO has a significant effect on the PTZ-induced seizure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Oxidoreductases / antagonists & inhibitors*
  • Animals
  • Arginine / analogs & derivatives*
  • Arginine / pharmacology
  • Calmodulin-Binding Proteins / antagonists & inhibitors*
  • Epilepsy / chemically induced
  • Epilepsy / drug therapy*
  • Male
  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide Synthase
  • Pentylenetetrazole
  • Rats
  • Rats, Wistar
  • omega-N-Methylarginine


  • Calmodulin-Binding Proteins
  • omega-N-Methylarginine
  • Arginine
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • NG-Nitroarginine Methyl Ester
  • Pentylenetetrazole