Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion

J Cardiovasc Pharmacol. 1994;24 Suppl 1:S9-15. doi: 10.1097/00005344-199424001-00003.

Abstract

The aim of the present study was to investigate the influence of moxonidine, a representative of I1-imidazoline-receptor agonist, on arrhythmias induced by myocardial ischemia or reperfusion. Acute myocardial infarction was produced by tightening a previously placed loose silk loop around the coronary artery in conscious rats. Moxonidine (0.01, 0.03, or 0.10 mg/kg i.v., 10 min before coronary ligation) significantly decreased the incidence of ventricular tachycardia during the first 15 min of infarction (70 versus 100% in controls), and the number of animals that survived without developing any arrhythmia was increased (15, 20, and 25%, respectively, versus 0%). Reperfusion-induced arrhythmias were produced by releasing a snare after 6 min of myocardial ischemia in anesthetized, artificially ventilated rats. Reperfusion rapidly induced severe dysrhythmias in all of the control animals. Moxonidine pretreatment (0.03 and 0.10 mg/kg) decreased the incidence of ventricular fibrillation (25 and 30% versus 64%) and increased the number of animals that survived without developing any arrhythmia (20 and 25% versus 0%). We conclude that moxonidine offers significant protection against the development of arrhythmias induced by acute regional myocardial ischemia in conscious rats. Moxonidine pretreatment also provides a beneficial effect during reperfusion-induced arrhythmias that appear after a brief period of myocardial ischemia.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Arrhythmias, Cardiac / drug therapy*
  • Arrhythmias, Cardiac / etiology
  • Coronary Vessels / drug effects
  • Coronary Vessels / surgery
  • Disease Models, Animal
  • Heart Rate / drug effects
  • Imidazoles / administration & dosage
  • Imidazoles / pharmacology
  • Imidazoles / therapeutic use*
  • Imidazoline Receptors
  • Ligation
  • Male
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / pathology
  • Myocardial Reperfusion Injury / complications
  • Myocardial Reperfusion Injury / drug therapy*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Drug / drug effects
  • Tachycardia / drug therapy
  • Ventricular Fibrillation / prevention & control

Substances

  • Antihypertensive Agents
  • Imidazoles
  • Imidazoline Receptors
  • Receptors, Drug
  • moxonidine