Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin

Infection. 1976;4(2):107-9. doi: 10.1007/BF01638726.

Abstract

Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated each aminoglycoside to a similar extent by a degree which varied according to the medium of incubaiton, the least inactivation being seen in pooled human serum and the most in phosphate buffer at pH 7.4.

MeSH terms

  • Amikacin / blood
  • Aminoglycosides / blood*
  • Anti-Bacterial Agents / blood*
  • Biotransformation
  • Carbenicillin / blood*
  • Drug Interactions
  • Gentamicins / blood
  • Humans
  • Hydrogen-Ion Concentration
  • Penicillins / blood*
  • Ticarcillin / blood*
  • Tobramycin / blood

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Gentamicins
  • Penicillins
  • Amikacin
  • Ticarcillin
  • Carbenicillin
  • Tobramycin