Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation

Immunol Today. 1995 Feb;16(2):71-6. doi: 10.1016/0167-5699(95)80091-3.


The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Autoantigens / immunology*
  • Epitopes / immunology*
  • Humans
  • Immune Tolerance / immunology*
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*


  • Autoantigens
  • Epitopes