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, 1 (4), 317-25

The Role of CD40 and CD80 Accessory Cell Molecules in Dendritic Cell-Dependent HIV-1 Infection

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The Role of CD40 and CD80 Accessory Cell Molecules in Dendritic Cell-Dependent HIV-1 Infection

L M Pinchuk et al. Immunity.

Abstract

We investigated the role of blood dendritic cells (DCs) in transmission of HIV-1 from infected to uninfected CD4+ T cells, and the accessory molecules involved. DCs promoted transmission from infected to uninfected CD4+ cells, but DCs themselves were not infectable. DC-mediated transmission was blocked by MAb to CD4 and MHC class II, but strongly increased by MAb to CD40 on DCs or CD28 on T cells. The DC-dependent infection was inhibitable by anti-CD80 and a soluble fusion protein of the CD80 ligand, CTLA4; soluble CTLA4 immunoglobulin also blocked infection augmented by cross-linking CD40. These data suggest a linkage between CD40-CD40L and CD28-CD80 counterreceptors on DCs and T cells, and spread of HIV infection in vivo.

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