Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 267 (5206), 2000-3

Altered Cytokine Export and Apoptosis in Mice Deficient in interleukin-1 Beta Converting Enzyme

Affiliations

Altered Cytokine Export and Apoptosis in Mice Deficient in interleukin-1 Beta Converting Enzyme

K Kuida et al. Science.

Abstract

The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development.

Similar articles

See all similar articles

Cited by 467 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback