Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes

Arthritis Rheum. 1995 Apr;38(4):485-91. doi: 10.1002/art.1780380405.


Objective: To determine whether apoptosis occurs in rheumatoid arthritis (RA) synoviocytes, and if this phenomenon is dependent on the Fas/Apo-1 pathway.

Methods: Apoptotic change in vivo was examined in RA synovial cells by several standard methods. The ability of cells to undergo Fas-induced apoptosis was determined in vitro.

Results: Typical apoptotic change was demonstrated in RA synovial cells by each method. Anti-Fas antibody induced apoptotic synovial cell death in vitro.

Conclusion: This is the first reported study to demonstrate apoptosis in RA synovial cells. The findings indicate that rheumatoid synoviocytes undergo Fas-mediated apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / immunology
  • Antigens, Surface / analysis*
  • Antigens, Surface / immunology
  • Apoptosis*
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / pathology*
  • Genetic Techniques
  • Humans
  • Microscopy, Electron
  • Synovial Membrane / immunology*
  • Synovial Membrane / pathology*
  • fas Receptor


  • Antibodies
  • Antigens, Surface
  • fas Receptor