Neonates treated with ECMO: predictive value of early CT and US neuroimaging findings on short-term neurodevelopmental outcome

Radiology. 1995 May;195(2):407-12. doi: 10.1148/radiology.195.2.7536947.


Purpose: To determine if neuroimaging findings in infants who undergo extracorporeal membrane oxygenation (ECMO) are predictive of developmental outcome.

Materials and methods: At 1-2 years of age, 183 ECMO survivors (69 female, 114 male) underwent developmental examination. Neuroimaging studies obtained at time of ECMO were assigned a neuroimaging score. Neuroimaging findings were correlated with developmental outcome.

Results: Eighty-five infants had neuroimaging abnormalities. Development was normal in 105 infants, suspect in 37, and delayed in 41. Mean neuroimaging scores were significantly worse in survivors with delayed development (P < or = .0001). The sensitivity and specificity of normal neuroimaging findings in prediction of normal outcome were 65% and 63%, respectively. Survivors with nonhemorrhagic abnormalities had a higher risk of delayed development than did those with isolated hemorrhagic abnormalities (39% vs 21%).

Conclusion: Although they cannot be used alone to predict outcome, early neuroimaging scores can be used to assign risk categories for developmental outcome.

MeSH terms

  • Brain / diagnostic imaging*
  • Brain Diseases / diagnostic imaging*
  • Brain Diseases / epidemiology
  • Cerebral Hemorrhage / diagnostic imaging*
  • Cerebral Hemorrhage / epidemiology
  • Child, Preschool
  • Developmental Disabilities / epidemiology*
  • Echoencephalography*
  • Extracorporeal Membrane Oxygenation*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Logistic Models
  • Male
  • Predictive Value of Tests
  • Risk Factors
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed