Activity of pp60c-src in 60 different cell lines derived from human tumors

Cancer Biochem Biophys. 1994 Oct;14(3):171-5.

Abstract

The activity of the protein tyrosine kinase pp60c-src was determined for each of the 60 human cell lines in the panel used by the National Cancer Institute for the random screening of potential anticancer drugs. The leukemia, lymphoma, melanoma, and small-cell lung cancer derived cell lines had low pp60c-src activity. Surprisingly, non-small-cell lung and ovarian cell lines had a median pp60c-src activity which was greater than that of the panel of cells representing colon cancer, which is most often associated with elevated pp60c-src activity. This data defines homologous cell lines which contain low and high pp60c-src activity which will aid attempts to understand the role of this enzyme in human cancer.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Small Cell / metabolism
  • Cell Line
  • Central Nervous System Neoplasms / metabolism
  • Colonic Neoplasms / metabolism
  • Female
  • Humans
  • Kidney Neoplasms / metabolism
  • Leukemia / metabolism
  • Lung Neoplasms / metabolism
  • Lymphoma / metabolism
  • Melanoma / metabolism
  • Ovarian Neoplasms / metabolism
  • Proto-Oncogene Proteins pp60(c-src) / metabolism*
  • Tumor Cells, Cultured

Substances

  • Proto-Oncogene Proteins pp60(c-src)