Exocytotic Ca2+ channels in mammalian central neurons

Trends Neurosci. 1995 Feb;18(2):89-98.


Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca2+ is correspondingly heterogeneous. This review focuses on one element of this complex web that is of particular importance to neurobiologists: identifying which members of the voltage-dependent Ca(2+)-channel superfamily are responsible for the Ca2+ that enters nerve terminals and elicits vesicular release of chemical transmitters.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Calcium Channels, N-Type*
  • Central Nervous System / cytology*
  • Central Nervous System / metabolism*
  • Exocytosis / physiology*
  • Humans
  • Molecular Sequence Data
  • Neurons / metabolism*
  • Neurons / physiology


  • Calcium Channels
  • Calcium Channels, N-Type
  • voltage-dependent calcium channel (P-Q type)