Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo

Biol Pharm Bull. 1994 Dec;17(12):1686-8. doi: 10.1248/bpb.17.1686.

Abstract

Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB, and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency as BB > AB = AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest that possibility that three PDGF isoforms are indirect angiogenic factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Chick Embryo
  • Chorion / blood supply
  • Chorion / drug effects
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Isomerism
  • Neovascularization, Pathologic / chemically induced*
  • Neovascularization, Pathologic / physiopathology
  • Platelet-Derived Growth Factor / pharmacology*
  • Regional Blood Flow / drug effects

Substances

  • Platelet-Derived Growth Factor