Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction

Eur J Immunol. 1995 Apr;25(4):1125-8. doi: 10.1002/eji.1830250442.


Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen Presentation
  • Antigens, CD / immunology
  • Antigens, CD / metabolism*
  • Antigens, Differentiation, B-Lymphocyte / immunology
  • Antigens, Differentiation, B-Lymphocyte / metabolism*
  • CD40 Antigens
  • Cells, Cultured
  • Humans
  • Interleukin-12 / biosynthesis*
  • Lymphocyte Activation
  • Monocytes / immunology
  • Monocytes / metabolism*
  • T-Lymphocytes / immunology*


  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • CD40 Antigens
  • Interleukin-12