B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

Immunity. 1995 May;2(5):523-32. doi: 10.1016/1074-7613(95)90032-2.


The functional necessity for two CD28 counterreceptors (B7-1 and B7-2) is presently unknown. B7-1 and B7-2 equivalently costimulate IL-2 and interferon-gamma (IFN gamma) production and IL-2 receptor alpha and gamma chain expression. B7-2 induces significantly more IL-4 production than B7-1, with the greatest difference seen in naive T cells. Repetitive costimulation of CD4+ CD45RA+ T cells with B7-2 results in moderate levels of both IL-4 and IL-2, whereas repetitive costimulation with B7-1 results in high levels of IL-2 and low levels of IL-4. Therefore, B7-1 and B7-2 costimulation mediate distinct outcomes, since B7-2 provides an initial signal to induce naive T cells to become IL-4 producers, thereby directing the immune response more towards Th0/Th2, whereas B7-1 is a more neutral differentiative signal.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • Antigens, CD*
  • B7-1 Antigen / physiology*
  • B7-2 Antigen
  • CD4-Positive T-Lymphocytes / chemistry
  • CD4-Positive T-Lymphocytes / physiology*
  • CHO Cells
  • Cell Differentiation / drug effects
  • Cells, Cultured
  • Cricetinae
  • Gene Expression
  • Humans
  • Immunophenotyping
  • In Vitro Techniques
  • Interferon-gamma / biosynthesis
  • Interleukin-2 / biosynthesis
  • Interleukin-4 / biosynthesis*
  • Leukocyte Common Antigens / metabolism
  • Lymphocyte Culture Test, Mixed
  • Lymphotoxin-alpha / biosynthesis
  • Membrane Glycoproteins / physiology*
  • Mice
  • RNA, Messenger / genetics
  • Receptors, Interleukin-2 / metabolism
  • T-Lymphocyte Subsets / metabolism
  • Transfection


  • Antigens, CD
  • B7-1 Antigen
  • B7-2 Antigen
  • CD86 protein, human
  • Cd86 protein, mouse
  • Interleukin-2
  • Lymphotoxin-alpha
  • Membrane Glycoproteins
  • RNA, Messenger
  • Receptors, Interleukin-2
  • Interleukin-4
  • Interferon-gamma
  • Leukocyte Common Antigens