Lipopolysaccharide toxicity-regulating proteins in bacteremia

J Infect Dis. 1995 May;171(5):1250-7. doi: 10.1093/infdis/171.5.1250.

Abstract

The toxicity of lipopolysaccharide (LPS) is modified by several proteins, such as bactericidal/permeability-increasing protein (BPI) and LPS-binding protein (LBP). BPI and LBP plasma levels were measured in patients with gram-negative (n = 36) or gram-positive (n = 28) bacteremia. Levels of BPI and LBP, which are proteins that neutralize and enhance LPS effects, respectively, were increased before bacteremia was first detected. The BPI/neutrophil ratio, reflecting neutrophil activation, was significantly associated with the presence of sepsis syndrome and death in bacteremic patients: 1.06 (0.11-6.49) versus 0.57 (0.06-3.82) in patients with and without sepsis syndrome (P < .01), respectively, and 0.64 (0.06-3.82) versus 1.02 (0.12-6.49) in survivors and nonsurvivors (P < .05), respectively (ratio in nanograms of BPI per 10(6) neutrophils). High LBP peak levels were significantly associated with the presence of sepsis syndrome (P < .01). No differences in BPI and LBP levels were observed in patients with gram-negative versus gram-positive bacteremia. BPI/neutrophil ratio, as a parameter of neutrophil activation, may be useful in monitoring infectious disease.

Publication types

  • Comparative Study

MeSH terms

  • Acute-Phase Proteins / analysis*
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / blood
  • Antigens, Differentiation, Myelomonocytic / blood
  • Antimicrobial Cationic Peptides
  • Bacteremia / blood*
  • Bacteremia / mortality
  • Blood Proteins / analysis*
  • Carrier Proteins / blood*
  • Cell Count
  • Female
  • Gram-Negative Bacterial Infections / blood*
  • Gram-Negative Bacterial Infections / mortality
  • Gram-Positive Bacterial Infections / blood
  • Gram-Positive Bacterial Infections / mortality
  • Humans
  • Lipopolysaccharide Receptors
  • Male
  • Membrane Glycoproteins*
  • Membrane Proteins*
  • Middle Aged
  • Neutrophil Activation
  • Neutrophils
  • Prospective Studies
  • Survival Rate

Substances

  • Acute-Phase Proteins
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Antimicrobial Cationic Peptides
  • Blood Proteins
  • Carrier Proteins
  • Lipopolysaccharide Receptors
  • Membrane Glycoproteins
  • Membrane Proteins
  • bactericidal permeability increasing protein
  • lipopolysaccharide-binding protein