Abstract
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens / analysis
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Antigens, CD / immunology*
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Antigens, CD1
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Antigens, Surface
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Cell Line
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Humans
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Hybridomas
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Interleukin-4 / metabolism
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Lectins, C-Type
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Ligands
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Mice
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Mice, Inbred C57BL
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NK Cell Lectin-Like Receptor Subfamily B
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Proteins / analysis
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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T-Lymphocytes / immunology*
Substances
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Antigens
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Antigens, CD
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Antigens, CD1
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Antigens, Surface
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KLRB1 protein, human
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Lectins, C-Type
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Ligands
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NK Cell Lectin-Like Receptor Subfamily B
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Proteins
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Receptors, Antigen, T-Cell, alpha-beta
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Interleukin-4