CD1 recognition by mouse NK1+ T lymphocytes

Science. 1995 May 12;268(5212):863-5. doi: 10.1126/science.7538697.

Abstract

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens / analysis
  • Antigens, CD / immunology*
  • Antigens, CD1
  • Antigens, Surface
  • Cell Line
  • Humans
  • Hybridomas
  • Interleukin-4 / metabolism
  • Lectins, C-Type
  • Ligands
  • Mice
  • Mice, Inbred C57BL
  • NK Cell Lectin-Like Receptor Subfamily B
  • Proteins / analysis
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • T-Lymphocytes / immunology*

Substances

  • Antigens
  • Antigens, CD
  • Antigens, CD1
  • Antigens, Surface
  • KLRB1 protein, human
  • Lectins, C-Type
  • Ligands
  • NK Cell Lectin-Like Receptor Subfamily B
  • Proteins
  • Receptors, Antigen, T-Cell, alpha-beta
  • Interleukin-4