Immunolocalization of adhesion molecules in psoriatic arthritis, psoriatic and normal skin

Br J Dermatol. 1995 Jan;132(1):32-8. doi: 10.1111/j.1365-2133.1995.tb08621.x.


Adhesion molecule expression in synovial membrane obtained from patients with psoriatic arthritis (PA) has previously been compared with rheumatoid arthritis (RA). Although expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) was similar in both psoriatic and rheumatoid synovium, in contrast, little or no endothelial leucocyte adhesion molecule-1 (ELAM-1) was observed in psoriatic synovium. In the present study, the expression of ICAM-1, ELAM-1 and VCAM-1 was examined in the involved and uninvolved skin from patients with PA (n = 15), patients with psoriasis (Ps) but no arthritis (n = 5) and in normal skin (n = 4). ICAM-1 was intensely expressed on endothelium and keratinocytes of involved skin from patients with Ps with or without arthritis. There was constitutive expression of ICAM-1 on endothelium only in uninvolved and normal skin. In contrast, ELAM-1 expression was restricted to endothelial cells; it was widespread and intense in involved skin, but was minimal in uninvolved and normal skin. VCAM-1 was expressed on endothelium, and also on some dendritic cells in involved psoriatic skin. There was minimal VCAM-1 staining on endothelial cells in uninvolved and normal skin. In conclusion, in involved psoriatic skin from patients with and without arthritis ICAM-1, ELAM-1 and VCAM-1 expression is up-regulated on vascular endothelium, and ICAM-1 is expressed on keratinocytes. However, ELAM-1 and VCAM-1 expression seen in dermal vessels is not found in psoriatic synovial vessels. These differences suggest a mechanism for controlling cellular traffic in Ps and in PA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Psoriatic*
  • Cell Adhesion Molecules / analysis*
  • Dendritic Cells / chemistry
  • E-Selectin
  • Endothelium / chemistry
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Intercellular Adhesion Molecule-1 / analysis
  • Keratinocytes / chemistry
  • Male
  • Middle Aged
  • Psoriasis*
  • Receptors, Immunologic / analysis
  • Skin / chemistry*
  • Vascular Cell Adhesion Molecule-1


  • Cell Adhesion Molecules
  • E-Selectin
  • Receptors, Immunologic
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1