Repulsive and inhibitory signals

Curr Opin Neurobiol. 1995 Feb;5(1):75-82. doi: 10.1016/0959-4388(95)80090-5.


Repulsive or inhibitory interactions between growth cones and their environment are now widely implicated in neural development and regeneration. Over the past year, descriptive studies of the various neuronal systems in which repulsion may participate have clarified its biology. Molecular and genetic studies have also provided the necessary entry point for further experimental manipulations, and are beginning to yield important clues regarding the function of repulsion in vivo. Although candidate second messengers underlying the growth cone response have been identified, they have yet to be incorporated into a comprehensive mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Central Nervous System / growth & development
  • Connectin
  • Glycoproteins / physiology
  • Muscle Proteins / physiology
  • Myelin Proteins / physiology
  • Myelin-Associated Glycoprotein
  • Nerve Regeneration
  • Neurons / physiology*
  • Protein Kinases*
  • Rats
  • Semaphorin-3A
  • Signal Transduction / physiology*


  • Connectin
  • Glycoproteins
  • Muscle Proteins
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Semaphorin-3A
  • Protein Kinases