The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution

Genomics. 1995 Jan 1;25(1):100-6. doi: 10.1016/0888-7543(95)80114-2.


CD36, CLA-1, and LIMPII are single polypeptide membrane glycoproteins, and the genes encoding them constitute a recently described gene family (D. Calvo and M. A. Vega (1993) J. Biol. Chem. 268: 18929). In the present paper, a cDNA encoding the human lysosomal membrane protein LIMPII was used to determine its expression pattern in cells of various lineages. Like CLA-1, and in contrast with the restricted expression of CD36, the expression of LIMPII is widespread. Mapping of the human LIMPII and CLA-1 genes (gene symbols CD36L2 and CD36L1, respectively) to specific chromosomes revealed that CLA-1, LIMPII, and CD36 do not form a gene cluster, but are found dispersed on chromosomes 12, 4, and 7, respectively. These data, together with the phylogenetic analysis carried out for the members of this family, indicate that the LIMPII, CLA-1, and CD36 genes diverged early in evolution from an ancestor gene, possibly before the divergence between the arthropods and the vertebrates.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / biosynthesis
  • Antigens, CD / genetics*
  • Base Sequence
  • Biological Evolution*
  • CD36 Antigens
  • Chromosome Mapping
  • Chromosomes, Human*
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 4
  • Chromosomes, Human, Pair 7
  • Cricetinae
  • DNA Primers
  • DNA, Complementary
  • Humans
  • Hybrid Cells
  • Lysosome-Associated Membrane Glycoproteins
  • Membrane Glycoproteins / biosynthesis
  • Membrane Glycoproteins / genetics*
  • Membrane Proteins*
  • Molecular Sequence Data
  • Multigene Family*
  • Phylogeny
  • Platelet Membrane Glycoproteins / biosynthesis
  • Platelet Membrane Glycoproteins / genetics*
  • Polymerase Chain Reaction
  • Receptors, Immunologic*
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Sequence Homology, Amino Acid
  • Sialoglycoproteins*


  • Antigens, CD
  • CD36 Antigens
  • DNA Primers
  • DNA, Complementary
  • Lysosome-Associated Membrane Glycoproteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Platelet Membrane Glycoproteins
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • SCARB1 protein, human
  • SCARB2 protein, human
  • Scavenger Receptors, Class B
  • Sialoglycoproteins