Islet amyloid polypeptide in pancreatic tissue of children with persistent hyperinsulinemic hypoglycemia caused by primary islet hyperplasia and nesidioblastosis

J Clin Endocrinol Metab. 1995 Jun;80(6):1956-9. doi: 10.1210/jcem.80.6.7539820.


Islet amyloid is a recognized characteristic finding in insulinoma and secondary islet hyperplasia resulting from severe insulin resistance. Little information is available about the presence of islet amyloid in primary islet hyperplasia (nesidioblastosis) of childhood. Here we report that islet amyloid was not present in 12 children with primary islet hyperplasia associated with hyperinsulinemic hypoglycemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid / metabolism*
  • Humans
  • Hyperplasia
  • Hypoglycemia / etiology
  • Hypoglycemia / metabolism*
  • Immunohistochemistry
  • Infant
  • Insulin / blood*
  • Islet Amyloid Polypeptide
  • Islets of Langerhans / metabolism*
  • Islets of Langerhans / pathology
  • Microscopy, Electron
  • Pancreas / metabolism*
  • Pancreas / pathology
  • Pancreatic Diseases / complications*
  • Pancreatic Diseases / metabolism
  • Staining and Labeling


  • Amyloid
  • Insulin
  • Islet Amyloid Polypeptide