Cornichon and the EGF Receptor Signaling Process Are Necessary for Both Anterior-Posterior and Dorsal-Ventral Pattern Formation in Drosophila

Cell. 1995 Jun 16;81(6):967-78. doi: 10.1016/0092-8674(95)90016-0.

Abstract

In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral signaling. cornichon, gurken, and torpedo also function in an earlier signaling event that establishes posterior follicle cell fates and specifies the anterior-posterior polarity of the egg chamber. Mutations in all three genes prevent the formation of a correctly polarized microtubule cytoskeleton required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Polarity / genetics
  • DNA / genetics
  • Drosophila / embryology*
  • Drosophila / genetics
  • Drosophila / physiology
  • Drosophila Proteins*
  • ErbB Receptors / genetics
  • ErbB Receptors / physiology
  • Female
  • Genes, Insect
  • Insect Hormones / genetics
  • Molecular Sequence Data
  • Mutation
  • Oocytes / metabolism
  • Oocytes / ultrastructure
  • Ovary / cytology
  • Ovary / embryology
  • RNA / genetics
  • RNA / metabolism
  • Signal Transduction
  • Transforming Growth Factor alpha*
  • Transforming Growth Factors / genetics

Substances

  • Drosophila Proteins
  • Insect Hormones
  • Transforming Growth Factor alpha
  • grk protein, Drosophila
  • RNA
  • Transforming Growth Factors
  • DNA
  • ErbB Receptors

Associated data

  • GENBANK/U28069