Malignant Liver Tumors Treated With MR Imaging-Guided Laser-Induced Thermotherapy: Technique and Prospective Results

Radiology. 1995 Jul;196(1):257-65. doi: 10.1148/radiology.196.1.7540310.


Purpose: To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases.

Materials and methods: In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot sequences was used to monitor therapy on-line, and dynamic and static contrast material-enhanced MR images enabled estimation of the degree of resultant necrosis. Follow-up studies were performed 3 months after thermotherapy.

Results: The thermosequences enabled accurate on-line monitoring in 85% of lesions. In 69% of lesions 20 mm in diameter or smaller, contrast-enhanced MR images depicted substantial necrosis, with a local tumor control rate of 69% after 6 months and 44% after 12 months. Among lesions larger than 20 mm, necrosis was frequently incomplete, with a local control rate of only 41% after 6 months and 27% after 12 months.

Conclusion: MR imaging-guided LITT of liver metastases is a safe and promising therapy for liver metastases.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Hyperthermia, Induced / methods*
  • Laser Therapy*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Palliative Care
  • Prospective Studies