Regulation of function and expression of P-selectin

Agents Actions Suppl. 1995;47:117-9. doi: 10.1007/978-3-0348-7343-7_10.

Abstract

P-selectin is an adhesion receptor for leukocytes that is expressed on activated platelets and endothelial cells. The surface expression of P-selectin is tightly regulated through signals in the cytoplasmic domain that mediate sorting into secretory granules, internalization into coated pits, and targeting to lysosomes for degradation. Like the other selectins, P-selectin binds sialylated, fucosylated carbohydrate ligands such as sialyl Lewis x. However, it binds with much higher affinity to PSGL-1, a sialomucin-like glycoprotein on myeloid cells. Binding of PSGL-1 to P-selectin may be essential for leukocytes to roll on P-selectin-expressing cells under shear forces.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Humans
  • Leukocytes / physiology
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / physiology
  • P-Selectin
  • Platelet Membrane Glycoproteins / biosynthesis
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / genetics
  • Platelet Membrane Glycoproteins / physiology*

Substances

  • Membrane Glycoproteins
  • P-Selectin
  • P-selectin ligand protein
  • Platelet Membrane Glycoproteins