Purification and cDNA sequence of a murine protein homologous to the human p62 tyrosine phosphoprotein that associates with the Ras GTPase-activating protein p120 GAP

Gene. 1995 Jun 9;158(2):307-8. doi: 10.1016/0378-1119(95)00040-d.

Abstract

A 68-kDa protein that binds to the murine dendritic cell-specific monoclonal antibody M342 was purified and its amino acid sequence was partially determined. Corresponding cDNA clones code for a protein that is closely related to a 62-kDa human protein (p62) that associates with the Ras GTPase-activating protein, p120 GAP, suggesting that p62 may have a dendritic cell-specific function or that an M342 cross-reactive epitope may exist on the murine p62 molecule.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Base Sequence
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / immunology
  • DNA-Binding Proteins / metabolism
  • Dendritic Cells*
  • Epitopes
  • GTPase-Activating Proteins
  • Gene Library
  • Humans
  • Mice
  • Molecular Sequence Data
  • Phosphoproteins / genetics*
  • Phosphoproteins / immunology
  • Phosphoproteins / metabolism
  • Proteins / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / immunology
  • RNA-Binding Proteins / metabolism
  • Sequence Analysis
  • Sequence Homology, Amino Acid
  • ras GTPase-Activating Proteins
  • ras Proteins / metabolism

Substances

  • Antibodies, Monoclonal
  • DNA, Complementary
  • DNA-Binding Proteins
  • DOK1 protein, human
  • Dok1 protein, mouse
  • Epitopes
  • GAP-associated protein p62
  • GTPase-Activating Proteins
  • Phosphoproteins
  • Proteins
  • RNA-Binding Proteins
  • ras GTPase-Activating Proteins
  • ras Proteins

Associated data

  • GENBANK/U17961