Abstract
A 68-kDa protein that binds to the murine dendritic cell-specific monoclonal antibody M342 was purified and its amino acid sequence was partially determined. Corresponding cDNA clones code for a protein that is closely related to a 62-kDa human protein (p62) that associates with the Ras GTPase-activating protein, p120 GAP, suggesting that p62 may have a dendritic cell-specific function or that an M342 cross-reactive epitope may exist on the murine p62 molecule.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal
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Base Sequence
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DNA, Complementary / genetics
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / immunology
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DNA-Binding Proteins / metabolism
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Dendritic Cells*
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Epitopes
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GTPase-Activating Proteins
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Gene Library
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Humans
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Mice
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Molecular Sequence Data
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Phosphoproteins / genetics*
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Phosphoproteins / immunology
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Phosphoproteins / metabolism
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Proteins / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / immunology
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RNA-Binding Proteins / metabolism
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Sequence Analysis
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Sequence Homology, Amino Acid
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ras GTPase-Activating Proteins
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ras Proteins / metabolism
Substances
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Antibodies, Monoclonal
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DNA, Complementary
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DNA-Binding Proteins
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DOK1 protein, human
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Dok1 protein, mouse
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Epitopes
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GAP-associated protein p62
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GTPase-Activating Proteins
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Phosphoproteins
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Proteins
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RNA-Binding Proteins
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ras GTPase-Activating Proteins
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ras Proteins